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Deep Learning for iPSC-CM Cardiotoxicity Screening
2026-09-20
Grafton et al. developed a high-content imaging and deep-learning workflow that assigns a single cardiotoxicity score to compounds tested in human iPSC-derived cardiomyocytes. The study shows how phenotype-first analysis can identify diverse liability classes early in drug discovery and guide follow-up testing before late-stage development.
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VX-661: F508del CFTR Corrector Guide
2026-09-19
VX-661 is a F508del CFTR corrector that improves folding, trafficking, and cell-surface expression of defective CFTR in experimental systems. Its activity is context-dependent: variant identity, calnexin-dependent proteostasis, exposure conditions, and combination with VX-770 can change the measured rescue.
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HyperScript™ Reverse Transcriptase for qPCR
2026-09-18
Learn how HyperScript™ Reverse Transcriptase (SKU K1071) can support RNA-to-cDNA conversion when cell viability, proliferation, or cytotoxicity studies generate limited or structurally complex RNA. This scenario-based guide separates product-supported capabilities from workflow recommendations for more defensible qPCR interpretation.
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2'-O-Methyladenosine: Assay Workflow Guide
2026-09-18
Build more reliable nucleoside transport, RNA modification, and purine metabolomics experiments with 2'-O-Methyladenosine. This guide translates a high-sensitivity UHPLC–MS/MS workflow into practical preparation, extraction, assay, and troubleshooting decisions.
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Nigericin as a Causal Probe of Ion–Metabolism Coupling
2026-09-17
Nigericin is a potassium/hydrogen ion carrier that converts membrane-gradient disruption into a measurable biological perturbation. This article connects intracellular pH modulation and mitochondrial ion transport with metabolism-aware assay design, while clarifying what recent antibiotic-resistance research does—and does not—demonstrate.
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Nullscript: Reliable HDAC Assay Design
2026-09-17
This scenario-driven guide explains how Nullscript (SKU C3606) can support reproducible HDAC, viability, proliferation, and cytotoxicity workflows. It covers assay compatibility, stock preparation, interpretation of transcriptional inactivity, cardiac ischemia/reperfusion relevance, and practical product-selection criteria.
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LNP-mRNA Fibroblasts for Intervertebral Disc Degeneration
2026-09-16
The reference study develops fibroblasts engineered with lipid nanoparticle-delivered mRNA to produce TNF-α-neutralizing antibodies within the degenerative disc environment. In inflammatory and rat intervertebral disc degeneration models, the engineered cells outperformed naive fibroblasts by preserving cell function, reducing inflammatory signaling, restoring extracellular matrix production, and improving disc height.
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HyperScript™ Reverse Transcriptase for Adipose qPCR
2026-09-16
HyperScript™ Reverse Transcriptase can strengthen RNA to cDNA conversion when adipose-tissue transcripts are scarce or structurally challenging. This article connects enzyme selection with the interpretation of Netrin-1, PPARγ, and Wnt/β-catenin expression assays in obesity research.
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Lysoptosis: A Conserved Serpin-Regulated Death Pathway
2026-09-15
The reference study defines lysoptosis as an evolutionarily conserved lysosome-dependent cell death pathway in which lysosomal membrane permeabilization and cathepsin release drive cellular demise when intracellular serpins are absent. Its cross-species genetic and cell-biological evidence separates lysoptosis from incidental lysosomal damage associated with other regulated cell death programs.
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PF-562271 HCl for FAK/Pyk2 Cancer Research
2026-09-15
PF-562271 HCl enables controlled interrogation of FAK/Pyk2 signaling in tumor-cell, stromal, and immune-cell assays. Its reversible, ATP-competitive profile complements radiotherapy and checkpoint-blockade models by linking pathway inhibition with tumor growth, metastasis, and immune-response measurements.
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Budesonide B1900: Reliable Cell Assays
2026-09-14
This scenario-driven guide shows how Budesonide SKU B1900 can improve interpretation of viability, proliferation, cytotoxicity, and airway-inflammation experiments. It connects formulation data with pulmonary permeability evidence and practical controls for reproducible laboratory workflows.
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Shrimp STING Reveals an Ancestral DNA-Sensing Axis
2026-09-14
Li and colleagues show that Litopenaeus vannamei STING can recognize both double-stranded DNA and cyclic dinucleotides, linking nucleic-acid detection to an IFN-like antiviral response in a marine invertebrate. The study defines a dsDNA–STING–IKKε–IRF–Vago4 pathway and provides evidence that core DNA-sensing functions extend beyond vertebrates.
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AG-221 Enasidenib Workflows for IDH2 AML
2026-09-13
Build mechanism-led IDH2-mutant AML assays around AG-221 (Enasidenib), linking 2-hydroxyglutarate reduction to differentiation, metabolism, and resistance biology. The workflow distinguishes direct mutant-IDH2 inhibition from downstream CD44-dependent vulnerabilities, making it more informative than viability testing alone.
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BV6 IAP Antagonist: Assay Workflows & Insights
2026-09-12
BV6 is a Smac-mimetic IAP antagonist for mapping apoptosis, therapy sensitization, and cell-death pathway crosstalk. This practical guide connects NSCLC radiosensitization and chemotherapy workflows with lessons from a recent ovarian-cancer muscle study, emphasizing time-resolved, orthogonal readouts over single-marker conclusions.
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HyperScript™ Reverse Transcriptase for HCC qPCR
2026-09-12
Learn how a thermally stable, low-RNase H enzyme can improve RNA-to-cDNA workflows for structured, scarce, or long transcripts. This practical guide translates a hepatocellular carcinoma study into assay design, control strategy, and troubleshooting decisions for qPCR laboratories.